§ · CORPUS COVERAGE

Coverage

The regulatory corpus Preclari draws on: every source in the corpus today, the sources on the roadmap, and the jurisdictions and domains not yet covered. If your jurisdiction or domain isn't listed here, tell us. A new source goes into the corpus only after a recorded review of it passes. Public jurisdiction additions enter the shared corpus snapshot once they pass that review. Your workflow data does not.

Curated. No crawling.

Covered today

in the corpus now

Pharma R&D · GCP & GLP

ICH E6(R3), Guideline for Good Clinical Practice (Principles, Annex 1, Annex 2)

ICH · retrieved 2026-05-27 · sha256:1daee6d9a6ed…

https://database.ich.org/sites/default/files/ICH_E6(R3)_Step4_FinalGuideline_2025_0106_ErrorCorrections_2025_1024.pdf

FDA 21 CFR Part 58, Good Laboratory Practice for Nonclinical Laboratory Studies

US · retrieved 2026-05-27 · sha256:6d35676e9e89…

https://www.ecfr.gov/current/title-21/chapter-I/subchapter-A/part-58

Manufacturing & quality · GxP

EudraLex Volume 4, EU Guidelines for Good Manufacturing Practice, Annex 11: Computerised Systems

EU · retrieved 2026-05-17 · sha256:8ec11211ba33…

https://health.ec.europa.eu/system/files/2016-11/annex11_01-2011_en_0.pdf

EudraLex Volume 4, EU Guidelines for Good Manufacturing Practice, Annex 15: Qualification and Validation

EU · retrieved 2026-05-20 · sha256:1c3dbbbdf058…

https://health.ec.europa.eu/document/download/7c6c5b3c-4902-46ea-b7ab-7608682fb68d_en?filename=2015-10_annex15.pdf

EudraLex Volume 4, EU Guidelines for Good Manufacturing Practice, Chapter 1: Pharmaceutical Quality System

EU · retrieved 2026-05-17 · sha256:11e87c3246ab…

https://health.ec.europa.eu/system/files/2016-11/vol4-chap1_2013-01_en_0.pdf

ICH Q10, Pharmaceutical Quality System

ICH · retrieved 2026-05-17 · sha256:396b99197692…

https://database.ich.org/sites/default/files/Q10%20Guideline.pdf

ICH Q9(R1), Quality Risk Management

ICH · retrieved 2026-05-17 · sha256:007a97272eec…

https://database.ich.org/sites/default/files/ICH_Q9%28R1%29_Guideline_Step4_2023_0126_0.pdf

MHRA 'GXP' Data Integrity Guidance and Definitions (Revision 1, March 2018)

UK · retrieved 2026-05-17 · sha256:e05dda11a933…

https://assets.publishing.service.gov.uk/media/5aa2b9ede5274a3e391e37f3/MHRA_GxP_data_integrity_guide_March_edited_Final.pdf

PIC/S PE 009-17, Guide to Good Manufacturing Practice for Medicinal Products, Part I, Chapter 1: Pharmaceutical Quality System

PICS · retrieved 2026-05-17 · sha256:7deb95a770fa…

https://picscheme.org/docview/6606

WHO Technical Report Series 1033, Annex 4, Guideline on Data Integrity

WHO · retrieved 2026-05-17 · sha256:7340cd60912b…

https://cdn.who.int/media/docs/default-source/medicines/norms-and-standards/guidelines/inspections/trs1033-annex4-guideline-on-data-integrity.pdf

PIC/S Guidance PI 011-3, Good Practices for Computerised Systems in Regulated 'GXP' Environments

PICS · retrieved 2026-05-19 · sha256:cc7ce49a671d…

https://picscheme.org/docview/3444

Electronic records & data integrity

Data Integrity and Compliance With Drug CGMP: Questions and Answers (Guidance for Industry)

US · retrieved 2026-05-17 · sha256:1b5074c592ed…

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/data-integrity-and-compliance-drug-cgmp-questions-and-answers

Part 11, Electronic Records; Electronic Signatures, Scope and Application (Guidance for Industry)

US · retrieved 2026-05-17 · sha256:306013031df6…

https://www.fda.gov/regulatory-information/search-fda-guidance-documents/part-11-electronic-records-electronic-signatures-scope-and-application

Roadmap

trigger-gated · by demand signal

EU GMP deepening (QP release)

EudraLex Volume 4, Annex 16, Certification by a Qualified Person and Batch Release

EudraLex · EU

Unlocks: QP decision-support AI

ICH Q7, Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients

ICH · ICH

Unlocks: API manufacturing AI workflows (deviation, OOS, change control)

FDA Draft Guidance, Considerations for the Use of Artificial Intelligence and Machine Learning in Drug Manufacturing AI-specific context

FDA · US

Unlocks: AI-specific GMP context for US workflows

Medtech (EU MDR + US FDA)

US FDA, 21 CFR Part 803, Medical Device Reporting

FDA · US

Unlocks: US adverse-event reporting workflows for AI-enabled medical devices

US FDA 21 CFR Part 820, the Quality Management System Regulation (QMSR); the QMSR final rule (89 FR 7496) amends Part 820 to incorporate ISO 13485:2016 by reference, applying from 2 February 2026

FDA · US

Unlocks: US medical device AI/ML quality system workflows under the QMSR (21 CFR Part 820 as amended in 2024 to incorporate ISO 13485:2016 by reference; compliance from 2 February 2026)

MHRA Medical Devices Guidance, UK CA marking path (post-Brexit)

MHRA · UK

Unlocks: UK CA marking decisions for AI-enabled medical devices

EU AI Act, high-risk systems

EBA Guidelines on loan origination and monitoring (EBA/GL/2020/06), § 4.3.4 (automated models in credit decisions)

EBA · EU

Unlocks: AI-assisted credit decision workflows; intersects with AI Act Annex III §5(b)

EBA Report, Machine Learning for IRB credit risk models (EBA/REP/2023/28)

EBA · EU

Unlocks: Machine learning in internal-ratings-based credit risk modelling, with model-risk governance and explainability requirements

ECB Guide to Internal Models, model governance expectations for SSM-supervised institutions

ECB · EU

Unlocks: Internal model governance expectations for euro-area supervised banks deploying AI in regulated functions

EU DORA, Regulation (EU) 2022/2554 on digital operational resilience for the financial sector

European Commission · EU

Unlocks: Operational resilience requirements for AI systems in financial services; intersects with AI Act on system reliability, third-party risk, and incident reporting (applies from January 2025)

NIST AI Risk Management Framework, parallel US framing (less prescriptive than the EU AI Act; complement, not substitute) AI-specific context

NIST · US

Unlocks: US-side AI risk management framing for buyers also subject to EU AI Act; would let one PIF address both regimes

Not yet covered

tell us if you need it

Japan, PMDA

Pharmaceuticals and Medical Devices Agency guidance not yet onboarded; translation and structural alignment required.

Tell us if: Your workflow touches Japanese market authorisations or PMDA-inspected sites.

China, NMPA

National Medical Products Administration guidance not yet onboarded; corpus requires NMPA-specific document curation.

Tell us if: Your workflow operates in or imports to mainland China and is regulated by NMPA.

India, CDSCO

Central Drugs Standard Control Organisation guidance not yet onboarded.

Tell us if: Your workflow involves CDSCO-regulated manufacturing or distribution.

Brazil, ANVISA

Agência Nacional de Vigilância Sanitária guidance not yet onboarded.

Tell us if: Your workflow operates under ANVISA jurisdiction.

Korea, MFDS

Ministry of Food and Drug Safety guidance not yet onboarded.

Tell us if: Your workflow involves Korean market authorisation or MFDS-inspected sites.

GCP and GLP, extended coverage

Tier-1 pharma R&D anchors are now onboarded: ICH E6(R3) GCP (ich-e6-r3-gcp) and FDA 21 CFR Part 58 GLP (fda-21cfr-58-glp). Still NOT covered: ICH E8(R1)/E9 (general clinical-study and statistical principles), EU Clinical Trials Regulation 536/2014, and FDA 21 CFR Part 312 (IND), adjacent clinical sources deferred to a later R&D tranche.

Tell us if: Your workflow needs ICH E8/E9, EU CTR 536/2014, or FDA Part 312 (IND) coverage beyond the onboarded GCP and GLP anchors.

OECD Principles of Good Laboratory Practice (Series No. 1)

Reference-only. The OECD GLP document's controlling copyright notice requires written permission for reproduction (and the 1998 document predates OECD's post-2024 CC BY 4.0 default), so its text is NOT reproduced under the B-3 verbatim gate. GLP requirements are carried verbatim by the US public-domain equivalent, FDA 21 CFR Part 58 (fda-21cfr-58-glp); OECD GLP is cited as a cross-reference only.

Tell us if: Your workflow specifically requires verbatim OECD GLP No. 1 clause text rather than the FDA Part 58 GLP equivalent.

Veterinary medicines

Veterinary GMP and EMA/CVMP veterinary medicines guidance are not yet onboarded. They differ enough from human-pharma GMP to warrant a separate corpus.

Tell us if: Your workflow is veterinary-pharma rather than human-pharma.

Switzerland, IvDV (In-vitro-Diagnostika-Verordnung, SR 812.219)

Swiss IVD ordinance (Switzerland's parallel to EU IVDR 2017/746) not yet onboarded. IvDV requires separate extraction under the same verbatim gate.

Tell us if: Your workflow involves Swiss in-vitro diagnostic devices regulated under IvDV.

IMDRF, MDSAP audit criteria

Medical Device Single Audit Program (MDSAP) audit approach and task descriptions (IMDRF/MDSAP WG/N9 and related documents) not yet extracted. MDSAP covers manufacturers in AU/BR/CA/JP/US.

Tell us if: Your workflow involves MDSAP audit readiness or single-audit participation.

Need a jurisdiction or domain not yet on this page?

If your workflow touches a jurisdiction, regulator, or GxP domain that isn't visible here yet, . Every new source passes a recorded review before it goes into the corpus.